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Invitrogen™ Thyroid Peroxidase Recombinant Rabbit Monoclonal Antibody (JE60-40)
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Catalog No. FEMA550707
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FEMA550707 100 μL
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Catalog No. FEMA550707 Supplier Invitrogen™ Supplier No. MA550707
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Description

Rabbit Recombinant Monoclonal Antibody

Positive control: Human thyroid tissue, human thyroid carcinoma tissue. Predicted band size: 103 kDa Subcellular Location: Membrane.

Thyroid Peroxidase is a gene that encodes for a membrane-bound glycoprotein, which functions as an enzyme and plays a crucial role in the proper functioning of the thyroid gland. This protein is responsible for the iodination of tyrosine residues in thyroglobulin and the formation of phenoxy-ester between pairs of iodinated tyrosines, which leads to the production of thyroid hormones such as thyroxine and triiodothyronine. Mutations in this gene are known to cause several disorders related to thyroid hormone production, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Several transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants remains undetermined. Diseases associated with TPO include Thyroid Dyshormonogenesis 2A and Congenital Hypothyroidism.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Thyroid Peroxidase
Applications Immunohistochemistry (Paraffin)
Classification Recombinant Monoclonal
Clone JE60-40
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene TPO
Gene Accession No. P07202
Gene Alias EC 1.11.1; LOW QUALITY PROTEIN: thyroid peroxidase; MSA; TDH2A; thyroid microsomal antigen; thyroid peroxidase; thyroid peroxidase (332 AA); thyroperoxidase; TPO; TPX; TPXEC 1.11.1.8
Gene Symbols TPO
Host Species Rabbit
Immunogen Recombinant protein within Human Thyroid Peroxidase/TPO aa 834-933/933.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7173
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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