Invitrogen™ TIA1/TIAL1 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA519240

Catalog No. PIPA519240

Description

This antibody is predicted to react with bovine, canine and mouse based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.

TIAL1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1) is a Protein Coding gene. Diseases associated with TIAL1 include Salpingitis Isthmica Nodosa and Spinal Muscular Atrophy. Among its related pathways are Signaling by GPCR and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is TIA1. The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008].

Specifications

• Antigen: TIA1/TIAL1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TIA1
• Gene Alias: 2310050N03Rik; 5330433G13Rik; aging-associated gene 7 protein; AI256674; AL033329; cytotoxic granule-associated RNA binding protein 1; cytotoxic granule-associated RNA-binding protein 1; MGC33401; mTIA-1; mTIAR; Nucleolysin TIA-1; nucleolysin TIA-1 isoform p40; Nucleolysin TIAR; OTTHUMP00000020602; OTTHUMP00000020605; p40-TIA-1; p40-TIA-1 (containing p15-TIA-1); RNA binding protein TIAR (TIA-1 related); RNA-binding protein TIA-1; TCBP; T-cell-restricted intracellular antigen-1; T-cluster binding protein; Tia; Tia1; TIA-1; TIA1 cytotoxic granule-associated RNA binding protein; TIA1 cytotoxic granule-associated RNA binding protein-like 1; TIA-1-related nucleolysin; TIA-1-related protein; Tial 1 cytotoxic granule-associated RNA- binding protein-like 1; TIAL1; Tial1 cytotoxic granule-associated RNA binding protein-like 1; Tial1 cytotoxic granule-associated RNA-binding protein-like 1; TIAR; WDM
• Host Species: Goat
• Purification Method: Ammonium Sulfate Precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 7072, 7073
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P31483, Q01085
• Gene Symbols: TIA1, TIAL1
• Immunogen: Synthetic peptide sequence (SPEITTEDIKSAFAP) corresponding to the internal amino acids of TIAL1 (aa 105-119).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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