Invitrogen™ TIAF1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103477

Catalog No. PIPA5103477

Description

Antibody detects endogenous levels of total TIAF1.

TIAF-1 (TGFB1-induced anti-apoptotic factor 1), also known as MYO18A, is a TGFB1-induced anti-apoptotic factor that functions to inhibit the cytotoxic effects of TNF-alpha, TRADD and FADD. It localizes to the nucleus and significantly up-regulated in activated helper T lymphocytes (TH2) in chronic kidney and liver allograft rejection. Suppression of TIAF1 expression by siRNA prevents UV irradiation-mediated p53 phosphorylation and nuclear translocation. TIAF1 is essential in the p53- and WOX1-mediated cell death and shows an aggregation-dependent control of tumor progression and metastasis, and regulation of cell death.

Specifications

• Antigen: TIAF1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TIAF1
• Gene Alias: 12 kDa TGF-beta-1-induced antiapoptotic factor; MAJN; molecule associated with Jak-3 N-terminal; MYO18A; MYSPDZ; SPR210; TGFB1-induced anti-apoptotic factor 1; TGF-beta-1-induced antiapoptotic factor 1; TIAF; TIAF1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9220
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O95411
• Gene Symbols: TIAF1
• Immunogen: A synthesized peptide derived from human TIAF1(Accession O95411), corresponding to amino acid residues N80-G115.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov