TICAM1 Mouse anti-Human, Clone: OTI1G7, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF800679

Catalog No. 50-166-5251

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

Specifications

• Antigen: TICAM1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: TICAM1
• Gene Alias: IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 148022
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI1G7
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q8IUC6
• Gene Symbols: TICAM1
• Immunogen: Human recombit protein fragment corresponding to amino acids 120-420 of human TICAM1 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1