Invitrogen™ TICAM2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA529576

Catalog No. PIPA529576

Description

Recommended positive controls: HCT116. Predicted reactivity: Pig (82%), Rhesus Monkey (97%), Chimpanzee (99%), Bovine (80%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

TRAM, or TRIF-related adaptor molecule (TICAM2), plays an essential role in the MyD88-independent signaling of TLR4. The functional absence of TRAM in vascular endothelial cells restricts TLR4 signaling to MyD88-dependent pathway. Overexpression of TRAM cDNA in endothelial cells reconstituted LPS-induced Trif-dependent NF-kB activation and cxcl10 promoter activity.

Specifications

• Antigen: TICAM2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TICAM2
• Gene Alias: B430113A10; cytoplasmic adaptor; MyD88-4; NF-kappa-B-activating protein 502; putative NF-kappa-B-activating protein 502; TAG; TICAM2; TICAM-2; TIR domain-containing adapter molecule 2; TIR domain-containing adapter protein; TIRAP3; Tirp; toll like receptor adaptor molecule 2; toll/interleukin-1 receptor (TIR) domain-containing adapter protein; toll/interleukin-1 receptor domain-containing protein; Toll-interleukin I receptor domain (TIR)-containing adaptor molecule (TICAM) 2; toll-like receptor adaptor molecule 2; toll-like receptor adaptor protein 3; Tram; Trif; TRIF-related adapter molecule; TRIF-related adapter molecule TRAM; TRIF-related adaptor molecule
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 353376
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.72 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q86XR7
• Gene Symbols: TICAM2
• Immunogen: Full length human TICAM2 Recombinant protein.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov