Invitrogen™ TIE2 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547963

Catalog No. PIPA547963

Description

In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) Tie-2, recombinant mouse Tie-2, and rhTie-1 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.

Specifications

• Antigen: TIE2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TEK
• Gene Alias: AA517024; Angiopoietin-1 receptor; CD202B; CD202b antigen; EC 2.7.10; EC 2.7.10.1; Endothelial tyrosine kinase; endothelial-specific receptor tyrosine kinase; endothelium-specific receptor tyrosine kinase 2; endothelium-specific receptor tyrosine kinase Tie-2; hTIE2; Hyk; mTIE2; p140 TEK; protein-tyrosine kinase Tie2; STK1; Tek; TEK receptor tyrosine kinase; TEK tyrosine kinase, endothelial; TEKT1; Tektin-1; Tie2; tie-2; tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; tyrosine kinases that contain immunoglobulin-like loops and epidermal growth factor-similar domains 2; tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor Tie-2; VMCM; VMCM1
• Host Species: Goat
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 30747
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Neutralization, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: O73791
• Gene Symbols: TEK
• Immunogen: Mouse myeloma cell line NS0-derived recombinant zebrafish Tie-2 Val22-His741.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Zebrafish
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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