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Invitrogen™ TIGIT Chimeric Recombinant Rabbit Monoclonal Antibody (1B4)
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Catalog No. PIMA548199
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200 μg
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PIMA548199 200 μg
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Catalog No. PIMA548199 Supplier Invitrogen™ Supplier No. MA548199
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: This antibody is specific for murine TIGIT.

TIGIT is a 26 kDa protein that belongs to the poliovirus receptor (PVR) family. It is expressed on NK cells, regulatory T cells, follicular T helper cells, memory CD4+ T cells, and CD8+ T cells, but not on B cells or naive CD4+ T cells. However, TIGIT can be upregulated on naive CD4+ T cells upon activation. TIGIT interacts with members of the PVR and PVR-like families, including CD155. This interaction mediates the engagement of NK and T cells with antigen-presenting cells, fibroblasts, and endothelial cells expressing PVR and PVR-like proteins. Binding of TIGIT to PVR leads to increased secretion of IL-10 and decreased secretion of IL-12B, promoting the generation of mature immunoregulatory dendritic cells and suppressing T cell activation. Through these interactions, TIGIT plays a significant role in modulating immune responses and maintaining immune homeostasis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TIGIT Chimeric
Applications ELISA, Flow Cytometry, Inhibition Assays, Western Blot
Classification Recombinant Monoclonal
Clone 1B4
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene TIGIT
Gene Accession No. P86176
Gene Alias ENSMUSG00000071552; T cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domains; TIGIT; V-set and immunoglobulin domain containing 9; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain containing 3; V-set and transmembrane domain-containing protein 3; VSIG9; VSTM3; Washington University cell adhesion molecule; WUCAM
Gene Symbols TIGIT
Host Species Rabbit
Immunogen This antibody was raised by immunising TIGIT-/- mice with recombinant murine TIGIT tetramers.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100043314
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG λ
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