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  6. Invitrogen™ TIGIT Recombinant Rabbit Monoclonal Antibody (BLR047F)

Invitrogen™ TIGIT Recombinant Rabbit Monoclonal Antibody (BLR047F)
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Catalog No. PIMA544289
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PIMA544289 100 μL
PIMA544290 10 μL
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Catalog No. PIMA544289 Supplier Invitrogen™ Supplier No. MA544289
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Description

Rabbit Recombinant Monoclonal Antibody

TIGIT Recombinant Monoclonal Antibody for Western Blot, IHC (P)

TIGIT is a 26 kDa protein that belongs to the poliovirus receptor (PVR) family. It is expressed on NK cells, regulatory T cells, follicular T helper cells, memory CD4+ T cells, and CD8+ T cells, but not on B cells or naive CD4+ T cells. However, TIGIT can be upregulated on naive CD4+ T cells upon activation. TIGIT interacts with members of the PVR and PVR-like families, including CD155. This interaction mediates the engagement of NK and T cells with antigen-presenting cells, fibroblasts, and endothelial cells expressing PVR and PVR-like proteins. Binding of TIGIT to PVR leads to increased secretion of IL-10 and decreased secretion of IL-12B, promoting the generation of mature immunoregulatory dendritic cells and suppressing T cell activation. Through these interactions, TIGIT plays a significant role in modulating immune responses and maintaining immune homeostasis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TIGIT
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone BLR047F
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation BBS with 0.09% sodium azide; pH 8.2
Gene TIGIT
Gene Accession No. Q495A1
Gene Alias ENSMUSG00000071552; T cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domains; TIGIT; V-set and immunoglobulin domain containing 9; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain containing 3; V-set and transmembrane domain-containing protein 3; VSIG9; VSTM3; Washington University cell adhesion molecule; WUCAM
Gene Symbols TIGIT
Host Species Rabbit
Immunogen A peptide representing a region between residue 194 and the C-terminus (residue 244) of human T-cell immunoreceptor with Ig and ITIM domains precursor (TIGIT).
Purification Method Purified
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 201633
Target Species Human
Content And Storage 2-8°C
Product Type Antibody
Form Liquid
Isotype IgG
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