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Invitrogen™ TIM-1 Monoclonal Antibody (219211), Alexa Fluor™ 488

Catalog No. PIMA523634
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100 Tests
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PIMA523634 100 Tests
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Catalog No. PIMA523634 Supplier Invitrogen™ Supplier No. MA523634

Description

Mouse Monoclonal Antibody

This antibody does not cross-react with recombinant mouse (rm) TIM-1, rmTIM-2, or rhTIM-3.

CD365 also known as T-cell immunoglobulin and mucin domain 1 (Tim-1) is a type 1 surface glycoprotein that consists of extracellular N-terminal immunoglobulin V-like domain and a mucin domain, and a short cytoplasmic tail. The endogenous ligand for CD365 is Tim-4. In addition, CD365 is known to be a cellular receptor or co-receptor for a number of viruses including hepatitis A and C viruses, Ebola virus, Marburg virus, Dengue virus, Zika virus, West Nile virus, and Japanese encephalitis virus. The direct binding of the viruses by CD365 occurs via phosphatildyl-serine exposed on viral envelopes. Polymorphisms within human CD365 gene (HAVCR1) are associated with susceptibility to infection and the disease severity. CD365 has also been implicated in the T cell co-stimulation. CD365 is primarily expressed in epithelial cells. It is also highly expressed in A549, 769-P and Caco-2 and cell lines. CD365 exists also as a soluble protein generated by metalloproteinase mediated proteolytic cleavage of the surface protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TIM-1
Applications Flow Cytometry
Classification Monoclonal
Clone 219211
Conjugate Alexa Fluor 488
Formulation Buffered saline solution with BSA and 0.09% sodium azide
Gene Havcr1
Gene Accession No. Q96D42
Gene Alias AI503787; CD365; HAVCR; HAVCR1; HAVcr-1; Hepatitis A virus cellular receptor 1; hepatitis A virus cellular receptor 1 homolog; Kidney injury molecule 1; Kim1; KIM-1; T cell immunoglobin domain and mucin domain protein 1; t cell immunoglobulin and mucin domain-containing protein 1; T cell membrane protein 1; T-cell immunoglobulin and mucin domain containing 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell immunoglobulin mucin family member 1; T-cell immunoglobulin mucin receptor 1; T-cell membrane protein 1; TIM; TIM1; TIM-1; TIMD1; TIMD-1
Gene Symbols Havcr1
Host Species Mouse
Immunogen Mouse myeloma cell line NS0-derived recombinant human TIM-1/KIM-1/HAVCR Ser21-Thr288.
Purification Method Protein A/G
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26762
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2b
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