TIM-3 (CD366), NA/LE Mouse anti-Human, Unlabeled, Clone: 7D3, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 565768

Catalog No. BDB565768

Description

The 7D3 monoclonal antibody specifically binds to T cell immunoglobulin mucin 3 (TIM-3) which is also known as, CD366, or T-cell immunoglobulin and mucin domain-containing protein 3 (TIMD-3/TIMD3). CD366 is encoded by the HAVCR2 /gene (Hepatitis A virus cellular receptor 2). CD366 is a type I transmembrane glycoprotein and belongs to the human TIM family (along with TIM-1 and TIM-4) within the immunoglobulin superfamily. CD366 is expressed on Th1, Tc1, Th17, Treg, NK T, and NK cells. CD366 is also expressed on dendritic cells, mast cells, monocytes, and macrophages. It is not expressed by Th2 and B cells. CD366 helps maintain peripheral immune tolerance and homeostasis. CD366 regulates macrophage activation and is a negative regulator of Th1 cell function. Crosslinking of cell surface CD366 by binding to Galectin-9 and/or phosphatidylserine appears to play an important role in either positively or negatively regulating leucocyte functions, such as cytokine production or the phagocytosis of apoptotic cells. CD366 may also be useful as an AML stem cell surface marker because it appears to be more highly expressed by AML leukemia stem cells than by normal bone marrow hematopoietic stem cells.

NA/LE

Specifications

• Antigen: TIM-3 (CD366), NA/LE
• Clone: 7D3
• Conjugate: Unconjugated
• Gene Alias: CD366, HAVCR2, TIM3, T cell immunoglobulin mucin-3, TIMD-3, KIM-3
• Immunogen: Human TIM-3
• Quantity: 500 μg
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C.

• Classification: Monoclonal
• Concentration: 1.0mg/mL
• Formulation: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG1 κ

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov