Invitrogen™ TIM17 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552690

Catalog No. PIPA552690

Description

Immunogen sequence: TRFASAQFPN GPQFAEDPSQ LPSTQLPSSP FGDYRQYQ Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 95%.

Translocation of nuclear encoded preproteins into the mitochondrial matrix requires the coordinated action of the translocases Tom and Tim, which are located in the outer mitochondrial membrane and the inner membrane, respectively. The mitochondrial preprotein translocases of the outer membrane (Tom) is a multi-subunit protein that contains at least eight proteins: four import receptor subunits (Tom70, Tom37, Tom22, and Tom20), three small proteins (Tom7, Tom6, and Tom5), and a structural component of the outer membrane channel (Tom40). The Tom machinery involves the import receptors, which initiate the binding of cytosolically synthesized preproteins to the outer membrane, and a general import pore (GIP), which promotes the translocation of various pre-proteins into the mitochondria. The TIM channel imports nuclear-encoded mitochondrial preproteins, and it involves three proteins, Tim17, Tim23 and Tim44, which are represented at equimolar ratios. Tim17 is expressed as two isoforms Tim17a and Tim17b, which differ only in their C termini sequences, and like Tim23, these proteins are ubiquitously expressed in fetal and adult tissues. Tim17 and Tim23 are integral membrane proteins that comprise the structural elements of the inner membrane channel by which the preproteins are transferred. The Tim44, on the other hand, is a largely hydrophilic protein that recruits the matrix located Hsp70 to the site where the preprotein emerges from the Tim channel.

Specifications

• Antigen: TIM17
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TIMM17A
• Gene Alias: 17kDa; fb82c12; Inner membrane preprotein translocase Tim17a; Mimt17; Mitochondrial import inner membrane translocase subunit Tim17-A; Mitochondrial import inner membrane translocase subunit Tim17-A-like protein; mitochondrial inner membrane translocase; mTim17a; preprotein translocase; Tim17; TIM17A; TIMM17; TIMM17A; timm17a protein; translocase of inner mitochondrial membrane 17 homolog A; translocase of inner mitochondrial membrane 17 homolog A (yeast); translocase of inner mitochondrial membrane 17a; translocator of inner mitochondrial membrane 17 kDa, a; translocator of inner mitochondrial membrane 17a; translocator of inner mitochondrial membrane a; wu:fb82c12
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10440
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q99595
• Gene Symbols: TIMM17A
• Immunogen: Recombinant protein corresponding to Human TIM17. Recombinant protein control fragment (Product #RP-90236).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov