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TIM3 Monoclonal Antibody (25F.1D6), FITC, Invitrogen™

Catalog No. PIMA517957
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100 μg
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Catalog No. Quantity
PIMA517957 100 μg
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Catalog No. PIMA517957 Supplier Thermo Scientific Supplier No. MA517957

Description

Rat Monoclonal Antibody

MA5-17957 targets TIM3 in FACS and IHC applications and shows reactivity with Mouse samples. The MA5-17957 immunogen is mouse T cell clone AE7 cells.

TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TIM3
Applications Flow Cytometry, Immunohistochemistry
Classification Monoclonal
Clone 25F.1D6
Concentration 0.1 mg/mL
Conjugate FITC
Formulation PBS with 4-5mg/mL BSA and 0.02% sodium azide
Gene Havcr2
Gene Accession No. Q8VIM0
Gene Alias CD366; FLJ14428; Havcr2; HAVcr-2; Hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2 homolog; kidney injury molecule-3; KIM-3; sCD366; soluble CD366; soluble TIM 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain containing 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim3; TIM-3; TIMD3; TIMD-3
Gene Symbols Havcr2
Host Species Rat
Immunogen Murine T cell clone AE7 cells
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 171285
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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