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TIM3 Monoclonal Antibody (25F.1D6), PE, Invitrogen™

Catalog No. PIMA517958
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50 μg
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Catalog No. Quantity
PIMA517958 50 μg
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Catalog No. PIMA517958 Supplier Thermo Scientific Supplier No. MA517958

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

Description

Rat Monoclonal Antibody

MA5-17958 targets TIM3 in FACS and WB applications and shows reactivity with Mouse samples. The MA5-17958 immunogen is mouse T cell clone AE7 cells.

TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TIM3
Applications Flow Cytometry
Classification Monoclonal
Clone 25F.1D6
Concentration 0.1 mg/mL
Conjugate PE
Formulation PBS with 4-5mg/mL BSA and 0.02% sodium azide
Gene Havcr2
Gene Accession No. Q8VIM0
Gene Alias CD366; FLJ14428; Havcr2; HAVcr-2; Hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2 homolog; kidney injury molecule-3; KIM-3; sCD366; soluble CD366; soluble TIM 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain containing 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim3; TIM-3; TIMD3; TIMD-3
Gene Symbols Havcr2
Host Species Rat
Immunogen Murine T cell clone AE7 cells
Purification Method Protein G
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 171285
Target Species Mouse
Content And Storage 4° C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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