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  6. Invitrogen™ TIM3 Recombinant Rabbit Monoclonal Antibody (BLR033F)

Invitrogen™ TIM3 Recombinant Rabbit Monoclonal Antibody (BLR033F)
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Catalog No. PIMA544261
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PIMA544261 100 μL
PIMA544262 10 μL
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Catalog No. PIMA544261 Supplier Invitrogen™ Supplier No. MA544261
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Description

Rabbit Recombinant Monoclonal Antibody

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TIM3
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone BLR033F
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation BBS with 0.09% sodium azide; pH 8.2
Gene Havcr2
Gene Accession No. Q8TDQ0
Gene Alias CD366; FLJ14428; Havcr2; HAVcr-2; Hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2 homolog; kidney injury molecule-3; KIM-3; sCD366; soluble CD366; soluble TIM 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain containing 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim3; TIM-3; TIMD3; TIMD-3
Gene Symbols Havcr2
Host Species Rabbit
Immunogen Recombinant protein representing the extracellular domain of human TIM3 (HAVCR2) (residues 22-201).
Purification Method Purified
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84868
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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