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Invitrogen™ TIMD2 Polyclonal Antibody
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Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5144073

Catalog No. PIPA5144073


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Description

Description

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: mouse liver tissue, mouse kidney tissue. IHC: mouse liver tissue, rat liver tissue. Flow: HEPA1-6 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

TIM-2 recognizes T-cell immunoglobulin mucin 2, a transmembrane glycoprotein and member of the immunoglobulin superfamily, expressed by activated lymphocytes, developmentally in the 8-cell embryo and blastocyst, and preferentially up-regulated in Th2 cells and down-regulated in Th1 cells. Tim-2 acts as a negative regulator of Th2 cells, and is implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses. Tim-2 also acts as a receptor for Semaphorin 4A, a transmembrane protein expressed on dendritic cells and B cells, which plays a role in the guidance of axonal migration during neuronal development, and has been shown to enhance T cell activation.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

TIMD2
Polyclonal
Unconjugated
Timd2
AA816106; AU019358; AU019662; C78111; G9D3; T cell immunoglobulin and mucin domain containing 2; T-cell immunoglobulin and mucin domain containing 2; T-cell immunoglobulin and mucin domain-containing protein 2; T-cell immunoglobulin mucin receptor 2; T-cell membrane protein 2; Tim2; TIM-2; Timd2; TIMD-2
Rabbit
Antigen affinity chromatography
RUO
171284, 287222
-20°C
Lyophilized
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
500 μg/mL
PBS with 4mg trehalose and no preservative
Q5FVR0, Q8R183
Timd2
A synthetic peptide corresponding to a sequence of mouse Tim 2/Timd2 (KKVVERTRCEDQVYIIEDTPYPEE).
100 μg
Primary
Mouse, Rat
Antibody
IgG
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