Invitrogen™ TIMD2 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547995

Catalog No. PIPA547995

Description

In direct ELISAs and Western blots, less than 2% cross-reactivity with recombinant human TIM-1 and recombinant mouse TIM-3 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

TIM-2 recognizes T-cell immunoglobulin mucin 2, a transmembrane glycoprotein and member of the immunoglobulin superfamily, expressed by activated lymphocytes, developmentally in the 8-cell embryo and blastocyst, and preferentially up-regulated in Th2 cells and down-regulated in Th1 cells. Tim-2 acts as a negative regulator of Th2 cells, and is implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses. Tim-2 also acts as a receptor for Semaphorin 4A, a transmembrane protein expressed on dendritic cells and B cells, which plays a role in the guidance of axonal migration during neuronal development, and has been shown to enhance T cell activation.

Specifications

• Antigen: TIMD2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Timd2
• Gene Alias: AA816106; AU019358; AU019662; C78111; G9D3; T cell immunoglobulin and mucin domain containing 2; T-cell immunoglobulin and mucin domain containing 2; T-cell immunoglobulin and mucin domain-containing protein 2; T-cell immunoglobulin mucin receptor 2; T-cell membrane protein 2; Tim2; TIM-2; Timd2; TIMD-2
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 171284
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Frozen), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q8R183
• Gene Symbols: Timd2
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse TIM-2 Met1-Asn229.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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