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Invitrogen™ TIMD2 Polyclonal Antibody
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Catalog No. PIPA547995
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100 μg
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PIPA547995 100 μg
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Catalog No. PIPA547995 Supplier Invitrogen™ Supplier No. PA547995
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Description

Goat Polyclonal Antibody

In direct ELISAs and Western blots, less than 2% cross-reactivity with recombinant human TIM-1 and recombinant mouse TIM-3 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

TIM-2 recognizes T-cell immunoglobulin mucin 2, a transmembrane glycoprotein and member of the immunoglobulin superfamily, expressed by activated lymphocytes, developmentally in the 8-cell embryo and blastocyst, and preferentially up-regulated in Th2 cells and down-regulated in Th1 cells. Tim-2 acts as a negative regulator of Th2 cells, and is implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses. Tim-2 also acts as a receptor for Semaphorin 4A, a transmembrane protein expressed on dendritic cells and B cells, which plays a role in the guidance of axonal migration during neuronal development, and has been shown to enhance T cell activation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TIMD2
Applications Immunohistochemistry (Frozen), Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene Timd2
Gene Accession No. Q8R183
Gene Alias AA816106; AU019358; AU019662; C78111; G9D3; T cell immunoglobulin and mucin domain containing 2; T-cell immunoglobulin and mucin domain containing 2; T-cell immunoglobulin and mucin domain-containing protein 2; T-cell immunoglobulin mucin receptor 2; T-cell membrane protein 2; Tim2; TIM-2; Timd2; TIMD-2
Gene Symbols Timd2
Host Species Goat
Immunogen Mouse myeloma cell line NS0-derived recombinant mouse TIM-2 Met1-Asn229.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 171284
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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Safety and Handling

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