Invitrogen™ TIMM8A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA597251

Catalog No. PIPA597251

Description

Immunogen sequence: MDSSSSSSAA GLGAVDPQLQ HFIEVETQKQ RFQQLVHQMT ELCWEKCMDK PGPKLDSRAE ACFVNCVERF IDTSQFILNR LEQTQKSKPV FSESLSD; Positive Samples: U-251MG, A-549, LO2, 293T, MCF-7, HeLa, Mouse liver, Mouse brain; Cellular Location: Intermembrane side, Mitochondrion inner membrane, Peripheral membrane protein.

Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development.

Specifications

• Antigen: TIMM8A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TIMM8A
• Gene Alias: DDP; Ddp1; deafness dystonia protein 1; Deafness dystonia protein 1 homolog; deafness/dystonia peptide; DFN1; DXHXS1274E; Fci-12; Mitochondrial import inner membrane translocase subunit Tim8 A; MTS; TIM8; Tim8a; Timm8a; Timm8a1; translocase of inner mitochondrial membrane 8 homolog a; translocase of inner mitochondrial membrane 8 homolog A (yeast); translocase of inner mitochondrial membrane 8 homolog a1; translocase of inner mitochondrial membrane 8 homolog A1 (yeast); translocase of inner mitochondrial membrane 8A1; X-linked deafness dystonia protein
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1678, 30058, 84383
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 2 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O60220, Q9WVA1, Q9WVA2
• Gene Symbols: TIMM8A, Timm8a1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-97 of human TIMM8A (NP_0040761).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov