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Invitrogen™ TIMP3 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA578423
Description
Positive Control: mouse kidney Predicted Reactivity: Human (100%), Rat (97%), Xenopus laevis (83%), Dog (100%), Rabbit (97%), Chicken (82%), Sheep (100%), Rhesus Monkey (100%), Bovine (97%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Tissue inhibitor of metalloproteinase 3 (TIMP3) is a member of the tissue inhibitor of metalloproteinases gene family. It functions to inhibit the activity of matrix metalloproteinases (MMP) which degrade components of the extracellular matrix. TIMP3 is expressed upon mitogenic stimulation. It binds irreversibly to zinc-dependent MMPs and inactivates them by binding to their catalytic zinc cofactor. Other functions of TIMP3 include nervous system development, tissue regeneration, and visual perception. In humans, the gene encoding TIMP3 is located on chromosome 22.
Specifications
TIMP3 | |
Polyclonal | |
Unconjugated | |
TIMP3 | |
HSMRK222; K222; K222TA2; Metalloproteinase inhibitor 3; MIG-5 protein; protein MIG-5; SFD; Sun; TIMP 3; TIMP metallopeptidase inhibitor 3; TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory); TIMP metallopeptidase inhibitor 3 L homeolog; timp3; TIMP-3; TIMP-3 protein; timp3.L; timp3-A; tissue inhibitor metalloproteinase-3; tissue inhibitor of metalloproteinase 3; tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); tissue inhibitor of metalloproteinase-3; tissue inhibitor of metalloproteinase-3 precursor; tissue inhibitor of metalloproteinases 3; tissue inhibitor of metalloproteinases-3; XELAEV_18002484mg | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
21859, 25358, 7078 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Western Blot, Immunocytochemistry | |
0.51 mg/mL | |
0.1M tris glycine with 10% glycerol, 0.1M glycine and 0.01% thimerosal; pH 7 | |
P35625, P39876, P48032 | |
TIMP3 | |
Recombinant protein encompassing a sequence within the center region of human TIMP3. The exact sequence is proprietary. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Safety and Handling
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