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Invitrogen™ TIN2 Polyclonal Antibody
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Catalog No. PIPA5121036
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PIPA5121036 100 μL
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Catalog No. PIPA5121036 Supplier Invitrogen™ Supplier No. PA5121036
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Description

Rabbit Polyclonal Antibody

Positive test controls include: MCF7, HepG2, Mouse skeletal muscle, Mouse heart. The target is usually found in the following locations: Chromosome, Nucleus, Nucleus matrix, telomere. Immunogen sequence: ECSVTDSVNL AEPMEQNPPQ QQRLALHNPL PKAKPGTHLP QGPSSRTHPE PLAGRHFNLA PLGRRRVQSQ WASTRGGHKE RPTVMLFPFR NLGSPTQVIS KPESKEEHAI YTADLAMGTR AASTGKSKSP CQTLGGRALK ENPVDLPATE QKENCLDCYM DPLRLSLLPP RARKPVCPPS LCSSVITIGD LVLDSDEEEN GQGEGKESLE NYQKTKFDTL IPTLCEYLPP SGHGAIPVSS CDCRDSSRPL.

TRF1 is a negative regulator of telomere length maintenance. Recently two proteins, tankyrase and Tin2, which bind to mammalian TRF1, have been identified. Tankyrase is a protein with homology to ankyrins as well as to the catalytic domain of poly (adenosine diphosphate-ribose) polymerase (PARP). Tankyrase localizes to telomeres by binding to the telomeric repeat binding factor 1 (TRF1) through its ankyrin repeats. Tankyrase exhibits PARP activity functioning as acceptors for adenosine diphosphate (ADP)-ribosylation. Since ADP-ribosylation of TRF1 diminishes its ability to bind to telomeric DNA, this suggests that telomere function in human cells is regulated by poly (ADP)-ribosylation. Both the cell cycle and TRF1 may regulate the subcellular localization of tankyrase. The cDNA coding for TIN2 protein was isolated as interacting partner of TRF1 from a yeast two-hybrid cDNA library screening. Tin2 localizes to telomeres and is essential for proper regulation of telomere length. TIN2, like TRF1, is widely and constitutively expressed, suggesting that these proteins act together to counterbalance telomere elongation by telomerase. However, endogenous TIN2, like endogenousTRF1, is not highly expressed, and therefore may be difficult to visualize by immunostaining in certain cell systems.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TIN2
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.61 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Tinf2
Gene Accession No. Q9BSI4, Q9QXG9
Gene Alias AW552114; D14Wsu146e; DKCA3; TERF1 (TRF1)-interacting nuclear factor 2; TERF1 interacting nuclear factor 2; TERF1-interacting nuclear factor 2; tin; TIN2; Tin-2; TINF2; TRF1-interacting nuclear factor 2; TRF1-interacting nuclear protein 2
Gene Symbols Tinf2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 202-451 of human TIN2/TIN2/TINF2 (NP_0010927441).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26277, 28113
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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