Invitrogen™ TIP47 Polyclonal Antibody

Catalog No.	Quantity
PA146161	100 μL

Catalog No. PA146161 Supplier Invitrogen™ Supplier No. PA146161

Description

Rabbit Polyclonal Antibody

In Western Blot analysis, a band is seen ~47 kDa (isoform B, containing the first 184 residues that isoform A is lacking). Suggested positive control: HeLa whole cell lysate and 3T3 L1 lysate.

TIP47 has been described as cargo protein involved in the trafficking of the mannose-6-phosphate receptor between endosomes and the Golgi complex. Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs and is required for endosome to Golgi transport. This protein also binds directly to the GTPase RAB9, a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. TIP47 has been localized in milk fat globule membranes of human and bovine origin. It has been described as a placental protein, as well. Increased amounts of TIP47 are secreted into circulation of cervix carcinoma patients. Therefore, this protein is probably significant as an oncodevelopmental marker.

Specifications

• Antigen: TIP47
• Applications: Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 0.05% sodium azide
• Gene: PLIN3
• Gene Accession No.: O60664, Q9DBG5
• Gene Alias: 1300012C15Rik; 47 kDa mannose 6-phosphate receptor-binding protein; 47 kDa MPR-binding protein; 47 kDa tail interaction protein; cargo selection protein TIP47; M6prbp1; mannose 6 phosphate receptor binding protein 1; mannose-6-phosphate receptor binding protein 1; mannose-6-phosphate receptor-binding protein 1; MGC11117; MGC2012; perilipin 3; perilipin-3; Placental protein 17; Plin3; PP17; tail-interacting protein, 47 kD; testicular tissue protein Li 114; TIP47; Unknown (protein for MGC:128897)
• Gene Symbols: PLIN3
• Host Species: Rabbit
• Immunogen: A synthetic peptide made to a region within the N-terminus (within residues 1-100) of the mouse TIP47 protein.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10226, 66905
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG