Invitrogen™ TIP47 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA584730

Catalog No. PIPA584730

Description

Immunogen sequence: DKTKSVVTGG VQSVMGSRLG QMVLSGVDTV LGKSEEWADN HLPLTDAELA RIATSLDGFD VASVQQQRQE Q.

TIP47 has been described as cargo protein involved in the trafficking of the mannose-6-phosphate receptor between endosomes and the Golgi complex. Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs and is required for endosome to Golgi transport. This protein also binds directly to the GTPase RAB9, a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. TIP47 has been localized in milk fat globule membranes of human and bovine origin. It has been described as a placental protein, as well. Increased amounts of TIP47 are secreted into circulation of cervix carcinoma patients. Therefore, this protein is probably significant as an oncodevelopmental marker.

Specifications

• Antigen: TIP47
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PLIN3
• Gene Alias: 1300012C15Rik; 47 kDa mannose 6-phosphate receptor-binding protein; 47 kDa MPR-binding protein; 47 kDa tail interaction protein; cargo selection protein TIP47; M6prbp1; mannose 6 phosphate receptor binding protein 1; mannose-6-phosphate receptor binding protein 1; mannose-6-phosphate receptor-binding protein 1; MGC11117; MGC2012; perilipin 3; perilipin-3; Placental protein 17; Plin3; PP17; tail-interacting protein, 47 kD; testicular tissue protein Li 114; TIP47; Unknown (protein for MGC:128897)
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10226
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O60664
• Gene Symbols: PLIN3
• Immunogen: Recombinant protein corresponding to Human PLIN3. Recombinant protein control fragment (Product #RP-104210).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov