Invitrogen™ TIP60 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA511216

Catalog No. PIPA511216

Description

This antibody is predicted to react with mouse and rat based on sequence homology.

TIP60 is a transcription factor, originally isolated as an HIV-1 TAT-interactive protein, known to interact with the viral TAT protein that leads to HTATIP polyubiquitination and targets it for degradation. It belongs to the MYST family of histone acetyl transferases (HATs). TIP60 is a catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. A co-regulator of transcription factors, TIP60 either promotes or suppresses tumorigenesis. TIP60 is an enzyme that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.

Specifications

• Antigen: TIP60
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KAT5
• Gene Alias: 60 kDa Tat-interactive protein; AI839539; cPLA(2)-interacting protein; CPLA2; cPLA2 interacting protein; ESA1; histone acetyltransferase HTATIP; Histone acetyltransferase KAT5; HIV-1 Tat interactive protein; HIV-1 tat interactive protein 1, 60 kDa homolog; HIV-1 tat interactive protein 1, homolog; HIV-1 Tat interactive protein 60 kD; HIV-1 Tat interactive protein, 60 kD; HIV-1 Tat interactive protein, 60kDa; HIV-1 tat interactive protein, homolog; HTATIP; Htatip1; K(lysine) acetyltransferase 5; K-acetyltransferase 5; Kat5; Lysine acetyltransferase 5; PLIP; Tat interacting protein, 60kDa; Tat-interactive protein-60; TIP; Tip55; Tip60; TIP60(HTATIP); Tip60b; ZC2HC5
• Host Species: Rabbit
• Purification Method: Ammonium sulfate precipitation, Size-exclusion - Dialysis
• Regulatory Status: RUO
• Gene ID (Entrez): 10524, 81601
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 2 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q8CHK4, Q92993
• Gene Symbols: KAT5
• Immunogen: KLH conjugated synthetic peptide between 33-64 amino acids from the N-terminal region of human KAT5 / Tip60/HTATIP.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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