Invitrogen™ TIP60 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA534794

Catalog No. PIPA534794

Description

Recommended positive controls: Jurkat, Jurkat nucleus. Predicted reactivity: Mouse (99%), Rat (99%), Pig (99%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

TIP60 is a transcription factor, originally isolated as an HIV-1 TAT-interactive protein, known to interact with the viral TAT protein that leads to HTATIP polyubiquitination and targets it for degradation. It belongs to the MYST family of histone acetyl transferases (HATs). TIP60 is a catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. A co-regulator of transcription factors, TIP60 either promotes or suppresses tumorigenesis. TIP60 is an enzyme that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.

Specifications

• Antigen: TIP60
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KAT5
• Gene Alias: 60 kDa Tat-interactive protein; AI839539; cPLA(2)-interacting protein; CPLA2; cPLA2 interacting protein; ESA1; histone acetyltransferase HTATIP; Histone acetyltransferase KAT5; HIV-1 Tat interactive protein; HIV-1 tat interactive protein 1, 60 kDa homolog; HIV-1 tat interactive protein 1, homolog; HIV-1 Tat interactive protein 60 kD; HIV-1 Tat interactive protein, 60 kD; HIV-1 Tat interactive protein, 60kDa; HIV-1 tat interactive protein, homolog; HTATIP; Htatip1; K(lysine) acetyltransferase 5; K-acetyltransferase 5; Kat5; Lysine acetyltransferase 5; PLIP; Tat interacting protein, 60kDa; Tat-interactive protein-60; TIP; Tip55; Tip60; TIP60(HTATIP); Tip60b; ZC2HC5
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10524, 81601
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.67 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q8CHK4, Q92993
• Gene Symbols: KAT5
• Immunogen: Recombinant fragment corresponding to a region within amino acids 61 and 292 of TIP60 (Uniprot ID#Q92993).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG