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Tocris Bioscience™ Tiplaxtinin
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Catalog No. 556510
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Description

Plasminogen activator inhibitor-1 (PAI-1) inhibitor

Tiplaxtinin is a plasminogen activator inhibitor-1 (PAI-1) inhibitor (IC50 = 2.7 μM). Induces vascular smooth muscle cell apoptosis in vitro and reduces carotid artery neointimal formation in a rat vascular injury model. Promotes thrombolysis in rat and dog models of acute arterial thrombosis. Orally available.

Specifications

Chemical Name or Material α-Oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-1H-indole-3-acetic acid
CAS 393105-53-8
Synonym PAI 039, tiplasinin
Quantity 10 mg
Target Additional Synthetic Protease Inhibitors
Molecular Formula C24H16F3NO4
Formula Weight 439.38
Purity >98%
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