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Invitrogen™ TIRAP Polyclonal Antibody
Goat Polyclonal Antibody
Supplier: Invitrogen™ PA518439
Description
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors. In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-βB and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling.
Specifications
TIRAP | |
Polyclonal | |
Unconjugated | |
TIRAP | |
AA407980; adapter protein wyatt; adaptor protein Wyatt; BACTS1; C130027E04Rik; FLJ42305; HGNC:17192; Mal; myD88 adapter-like protein; MyD88-2; OTTHUMP00000179130; TIR domain containing adaptor protein; TIR domain-containing adapter protein; TIRAP; Tlr4ap; toll/interleukin-1 receptor domain-containing adapter protein; toll-interleukin 1 receptor (TIR) domain containing adaptor protein; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; Toll-like receptor 4 adaptor protein; Toll-like receptor adaptor protein; Wyatt | |
Goat | |
Ammonium sulfate precipitation | |
RUO | |
114609 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
Western Blot | |
0.5 mg/mL | |
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3 | |
P58753 | |
TIRAP | |
Synthetic peptide sequence (QTLLKKPKKRPNSPE) corresponding to the internal amino acids of TIRAP (aa 27-42). | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG |
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