Invitrogen™ TIRAP Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520027

Catalog No. PIPA520027

Description

A suggested positive control is MCF7 cell lysate. PA5-20027 can be used with blocking peptide PEP-0146.

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors. In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-βB and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling.

Specifications

• Antigen: TIRAP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TIRAP
• Gene Alias: AA407980; adapter protein wyatt; adaptor protein Wyatt; BACTS1; C130027E04Rik; FLJ42305; HGNC:17192; Mal; myD88 adapter-like protein; MyD88-2; OTTHUMP00000179130; TIR domain containing adaptor protein; TIR domain-containing adapter protein; TIRAP; Tlr4ap; toll/interleukin-1 receptor domain-containing adapter protein; toll-interleukin 1 receptor (TIR) domain containing adaptor protein; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; Toll-like receptor 4 adaptor protein; Toll-like receptor adaptor protein; Wyatt
• Host Species: Rabbit
• Purification Method: Ion-exchange chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 114609
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P58753
• Gene Symbols: TIRAP
• Immunogen: A peptide corresponding to amino acids near the middle of human TIRAP.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG