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  6. 698110

Tocris Bioscience™ TL 0259

Selective and highly potent Fgr and Lyn kinase inhibitor; orally bioavailable

Supplier:  Tocris Bioscience™ 6981/10

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Catalog No. 69-811-0


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Description

Description

TL 0259 is a selective and highly potent Fgr and Lyn inhibitor (IC50 values are 0.03 and 0.1 nM, respectively). Exhibits selectivity for Fgr and Lyn over other Src family kinases and other nonreceptor and receptor tyrosine kinases. Suppresses proliferation of acute myelogenous leukemia (AML) cell lines in vitro. Eliminates leukemic cells from spleen and bone of mice bearing AML xenografts. Orally bioavailable.
Specifications

Specifications

3-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methylbenzamide dihydrochloride
10 mg
C32H34F3N5O4.2HCl
98%
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