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  5. Tocris Bioscience™ TL 0259

Tocris Bioscience™ TL 0259
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Catalog No. 698150
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Catalog No. Quantity
69-815-0 50 mg
69-811-0 10 mg
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Catalog No. 69-815-0 Supplier Tocris Bioscience™ Supplier No. 6981/50
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Description

Selective and highly potent Fgr and Lyn kinase inhibitor; orally bioavailable

TL 0259 is a selective and highly potent Fgr and Lyn inhibitor (IC50 values are 0.03 and 0.1 nM, respectively). Exhibits selectivity for Fgr and Lyn over other Src family kinases and other nonreceptor and receptor tyrosine kinases. Suppresses proliferation of acute myelogenous leukemia (AML) cell lines in vitro. Eliminates leukemic cells from spleen and bone of mice bearing AML xenografts. Orally bioavailable.

Specifications

Chemical Name or Material 3-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methylbenzamide dihydrochloride
Quantity 50 mg
Molecular Formula C32H34F3N5O4.2HCl
Purity 98%
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