TLE5/Amino-terminal enhancer of split Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-2202	100 μL

Catalog No. 50-198-2202 Supplier Bioss Supplier No. BS12392R

Description

Rabbit Polyclonal Antibody

Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. Amino-terminal enhancer of split (AES) is a member of the Groucho/ transducin-like enhancer of split (TLE) family of transcriptional regulators, a group of transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis. It has been suggested that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family. Interestingly, apoptosis of cells transfected with AES and Bit1 could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin.

Specifications

• Antigen: TLE5/Amino-terminal enhancer of split
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: TLE5
• Gene Accession No.: Q08117
• Gene Alias: AES; AES-1; AES-2; AL024115; Amino enhancer of split; Amino-terminal enhancer of split; Esp1; Gp130-associated protein GAM; Grg; GRG5; Grg-5; Groucho-related protein 5; Protein ESP1; Protein GRG; related to Drosophila groucho; R-esp1; TLE family member 5; TLE family member 5, transcriptional modulator; TLE5
• Gene Symbols: TLE5
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human TLE5/Amino-terminal enhancer of split.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 166
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG