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Invitrogen™ TLK2 Monoclonal Antibody (OTI2H2)
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Catalog No. PIMA526741
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100 μL
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Catalog No. Quantity
PIMA526741 100 μL
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Catalog No. PIMA526741 Supplier Invitrogen™ Supplier No. MA526741
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Description

Mouse Monoclonal Antibody

TLK2 Monoclonal Antibody for IHC (P)

TLK2 or Tousled-like kinase 2, is a nuclear serine/threonine kinases that is thought to be involved in the regulation of chromatin assembly. In addition, TLK2 is also involved in other cellular processes such as intracellular signaling cascade, protein amino acid phosphorylation, cell cycle, chromatin modification and in response to DNA damage stimulus. TLK2 displays maximal activity during S phase of the cell cycle where it appears to be regulated by cell-cycle-dependent phosphorylation. Inhibition of DNA replication causes a rapid loss of TLK2 activity, indicating that TLK2 function is tightly linked to ongoing DNA replication. The TLK2 enzyme is cell-cycle regulated, with maximal activity in S-phase. It is inactivated by phosphorylation at Ser-750, potentially by CHK1. TLK2 heterodimerizes with TLK1. This nuclear protein is widely expressed, with presence in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle tissues, and in several adult cell lines.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TLK2
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone OTI2H2
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Tlk2
Gene Accession No. Q86UE8
Gene Alias 4933403M19Rik; HsHPK; PKUalpha; PKU-alpha; protein kinase U-alpha; serine/threonine-protein kinase tousled-like 2; Tlk; Tlk2; tousled like kinase 2; tousled-like kinase 2; tousled-like kinase 2 (Arabidopsis)
Gene Symbols Tlk2
Host Species Mouse
Immunogen Human recombinant protein fragment corresponding to amino acids 1-296 of TLK2 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11011
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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