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TLK2 Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501559907
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20 μl; Unlabeled
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Catalog No.
50-155-9907 20 μl; Unlabeled
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Catalog No. 50-155-9907 Supplier Bethyl Laboratories, Inc Supplier No. A301257AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Mouse

TLK2, a member of the Ser/Thr protein kinase family, is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. The TLK2 enzyme is cell-cycle regulated, with maximal activity in S-phase. It is inactivated by phosphorylation at Ser-750, potentially by CHK1. TLK2 heterodimerizes with TLK1. This nuclear protein is widely expressed, with presence in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle tissues, and in several adult cell lines.

Specifications

Antigen TLK2
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene TLK2
Gene Accession No. Q86UE8
Gene Alias Serine/threonine-protein kinase tousled-like 2, Tousled-like kinase 2, PKU-alpha
Gene Symbols TLK2
Host Species Rabbit
Immunogen Between 722 and 772
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11011
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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