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TLR1 Monoclonal Antibody (GD2.F4), Invitrogen™

Catalog No. 01676537
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100 μg
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Catalog No. Quantity
01-676-537 100 μg
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Catalog No. 01-676-537 Supplier Thermo Scientific Supplier No. MA140167

Description

Mouse Monoclonal Antibody

MA1-40167 detects TLR1 from human samples. The MA1-40167 immunogen is human TLR1. Positive control: HeLa cells transfected with TLR1 mRNA; Negative control: Mock transfected HeLa cells.

TLR1 protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. The Toll-like receptor (TLR) family in mammals are comprised of a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. The TLRs could constitute an important and unrecognized component of innate immunity in humans. In mice, TLR1 interacts with TLR2 and co-expression of TLR1 and TLR2 enhance the NF-kappaB activation in response to a synthetic lipopeptide. They recognize the lipid configuration of the native mycobacterial lipoprotein as well as several tri-acylated lipopeptides. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for the TLR1 gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TLR1
Applications ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone GD2.F4
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA and 0.02% sodium azide
Gene TLR1
Gene Accession No. Q15399
Gene Alias CD281; KIAA0012; rsc786; TIL; TIL. LPRS5; TLR1; toll like receptor 1; Toll/interleukin-1 receptor-like protein; toll-like receptor 1
Gene Symbols TLR1
Host Species Mouse
Immunogen Human TLR1.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7096
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG1
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