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Invitrogen™ TLR4/MD-2 Complex Monoclonal Antibody (MTS510)
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Catalog No. PIMA516210
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100 μg
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Catalog No. Quantity
PIMA516210 100 μg
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Catalog No. PIMA516210 Supplier Invitrogen™ Supplier No. MA516210
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Description

Rat Monoclonal Antibody

Suggested positive control: Raw or thioglycolate-elicited mouse macrophage cells.

MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TLR4/MD-2 Complex
Applications Flow Cytometry, Immunoprecipitation
Classification Monoclonal
Clone MTS510
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA and 0.05% sodium azide
Gene Tlr4
Gene Accession No. O00206, Q9JHF9, Q9QUK6, Q9Y6Y9
Gene Alias ARMD10; CD284; Esop1; ESOP-1; hToll; lipopolysaccharide response; Lps; Ly87; Ly96; Ly-96; Lymphocyte antigen 96; Md2; MD-2; myeloid differentiation factor-2; myeloid differentiation protein-2; protein MD-2; Ran/M1; Rasl2-8; Tlr4; TLR-4; TOLL; Toll-like receptor 4
Gene Symbols Ly96, Tlr4
Host Species Rat
Immunogen Ba/F3 cell line expressing mouse TLR4 and MD-2.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17087, 21898, 23643, 7099
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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