Invitrogen™ TLR4/MD-2 Complex Monoclonal Antibody (MTS510)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA516210

Catalog No. PIMA516210

Description

Suggested positive control: Raw or thioglycolate-elicited mouse macrophage cells.

MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.

Specifications

• Antigen: TLR4/MD-2 Complex
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.05% BSA and 0.05% sodium azide
• Gene Accession No.: Q9JHF9, Q9QUK6
• Gene Symbols: Ly96, Tlr4
• Immunogen: Ba/F3 cell line expressing mouse TLR4 and MD-2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: Flow Cytometry, Immunoprecipitation
• Clone: MTS510
• Conjugate: Unconjugated
• Gene: Ly96
• Gene Alias: ARMD10; CD284; Esop1; ESOP-1; hToll; lipopolysaccharide response; Lps; Ly87; Ly96; Ly-96; Lymphocyte antigen 96; Md2; MD-2; myeloid differentiation factor-2; myeloid differentiation protein-2; protein MD-2; Ran/M1; Rasl2-8; Tlr4; TLR-4; TOLL; Toll-like receptor 4
• Host Species: Rat
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 17087, 21898
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid