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TLR5 Rabbit anti-Human, Mouse, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 198101AP

Catalog No. 50-173-2552



Description

Description

TLR5 is a Type I membrane protein belonging to the Toll-like receptor family, participates in the innate immune response to microbial agents. TLR5 also plays a role in mediating detection of bacterial flagellins. TLR5 acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. TLR5 protein binds to TIRAP and MyD88 via their respective TIR domains TLR5 is highly expressed in liver, and is detected in lung and at very low levels in most other tissues. The TLR5 gene lies in a locus that is associated with susceptibility to Salmonella. Inbred strains of mice can be classified into 3 categories according to their resistance to infection with S.typhimurium: susceptible (BALB/c, C57BL/6, C3H/He), intermediate (DBA/2, C75L) and resistant (A, CBA). The strain MOLF/Ei is highly susceptible to the infection, has a unique TLR5 haplotype and a lower expression of TRL5. A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires ft. disease and demonstrates the importance of TLR5 in the innate immune response.
Specifications

Specifications

TLR5
0.16 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O60602, Q9JLF7
SLEB1, TIL3, TLR5, toll like receptor 5
Rabbit
IgG
150 μL
-20°C
Primary
53791, 7100
Immunohistochemistry (Paraffin), Immunoprecipitation
Unconjugated
TLR5
Liquid
Tlr5
TLR5 Fusion Protein Ag13840
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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