TLR6 (CD286) Mouse anti-Human, PE, Clone: TLR6.127, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 566339

Catalog No. BDB566339

Description

The TLR6.127 monoclonal antibody specifically recognizes Toll-like receptor 6 (TLR6), which is also known as CD286. CD286 belongs to the mammalian Toll-like receptor (TLR) family of pattern recognition receptors that participate in inducing innate and adaptive immune responses to microbial pathogens. TLR6 is a type I transmembrane glycoprotein comprised of an extracellular domain with a large number of leucine?rich repeats (LRRs). Its cytoplasmic region contains a signaling Toll/Interleukin-1 Receptor (TIR) domain. TLR6 is expressed on monocytes, neutrophils, and some dendritic cells. In association with TLR2 (CD282), TLR6 recognizes diacylated lipopeptides and peptidoglycans of bacterial or fungal origin. The ligand-bound TLR2:TLR6 complex transduces responses intracellularly through MyD88 and the NF- B signaling cascade leading to the production of proinflammatory cytokines by responding cells.

R-phycoerythrin (PE) is an accessory photosynthetic pigment found in red algae. It exists in vitro as a 240-kDa protein with 23 phycoerythrobilin chromophores per molecule. This makes PE one of the brightest fluorochromes for flow cytometry applications, but its photobleaching properties make it unsuitable for fluorescence microscopy.

Specifications

• Antigen: TLR6 (CD286)
• Clone: TLR6.127
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG1 κ

• Classification: Monoclonal
• Conjugate: PE
• Gene Alias: Toll-like receptor 6, CD286
• Immunogen: Human TLR6 Transfected Cell Line
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.