TLR6 (CD286) Mouse anti-Human, PE, Clone: TLR6.127, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 566339
The TLR6.127 monoclonal antibody specifically recognizes Toll-like receptor 6 (TLR6), which is also known as CD286. CD286 belongs to the mammalian Toll-like receptor (TLR) family of pattern recognition receptors that participate in inducing innate and adaptive immune responses to microbial pathogens. TLR6 is a type I transmembrane glycoprotein comprised of an extracellular domain with a large number of leucine?rich repeats (LRRs). Its cytoplasmic region contains a signaling Toll/Interleukin-1 Receptor (TIR) domain. TLR6 is expressed on monocytes, neutrophils, and some dendritic cells. In association with TLR2 (CD282), TLR6 recognizes diacylated lipopeptides and peptidoglycans of bacterial or fungal origin. The ligand-bound TLR2:TLR6 complex transduces responses intracellularly through MyD88 and the NF- B signaling cascade leading to the production of proinflammatory cytokines by responding cells.R-phycoerythrin (PE) is an accessory photosynthetic pigment found in red algae. It exists in vitro as a 240-kDa protein with 23 phycoerythrobilin chromophores per molecule. This makes PE one of the brightest fluorochromes for flow cytometry applications, but its photobleaching properties make it unsuitable for fluorescence microscopy.
|Mouse BALB/c IgG1, κ|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Aqueous buffered solution containing BSA and ≤0.09% sodium azide.|
|Toll-like receptor 6, CD286|
|Human TLR6 Transfected Cell Line|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.|
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