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Invitrogen™ TLR7 Monoclonal Antibody (4F4)
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Catalog No. PIMA181963
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100 μg
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Catalog No. Quantity
PIMA181963 100 μg
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Catalog No. PIMA181963 Supplier Invitrogen™ Supplier No. MA181963
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Description

Mouse Monoclonal Antibody

In Western blot, this antibody detects a band at ~121 kDa in Ramos cell lysate. Mouse anti Human TLR7 antibody, clone 4F4 recognizes human TLR7 (toll-like receptor 7), a 121 kDa type I transmembrane protein belonging to the toll-like receptor (TLR) family.

TLR7 is a 10 amino acid long highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 LRR (leucine-rich) repeats and a TIR domain. TLR7 plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is activated by infections with single-stranded RNA viruses, including influenza virus and vesicular stomatitis virus (VSV). TLR7 is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8. TLR7 also acts via MyD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. TLR7 recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TLR7
Applications ELISA, Western Blot
Classification Monoclonal
Clone 4F4
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 10% glycerol and 0.02% sodium azide; pH 7.4
Gene TLR7
Gene Accession No. Q9NYK1
Gene Alias RGD1563357; RP23-139P21.3; Tlr7; TLR7-like; toll like receptor 7; toll-like receptor 7; toll-like receptor 7-like; UNQ248/PRO285
Gene Symbols TLR7
Host Species Mouse
Immunogen Recombinant human TLR7 (aa451-500) purified from E. coli.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51284
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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