Invitrogen™ TLR7 Recombinant Rabbit Monoclonal Antibody (3G6S4)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA535275

Catalog No. PIMA535275

Description

Immunogen sequence: SKKTVFVMTD KYAKTENFKI AFYLSHQRLM DEKVDVIILI FLEKPFQKSK FLQLRKRLCG SSVLEWPTNP QAHPYFWQCL KNALATDNHV AYSQVFKETV.

TLR7 is a 10 amino acid long highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 LRR (leucine-rich) repeats and a TIR domain. TLR7 plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is activated by infections with single-stranded RNA viruses, including influenza virus and vesicular stomatitis virus (VSV). TLR7 is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8. TLR7 also acts via MyD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. TLR7 recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.

Specifications

• Antigen: TLR7
• Classification: Recombinant Monoclonal
• Concentration: 0.85 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9NYK1
• Gene Symbols: TLR7
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 950-1049 of human TLR7 (Q9NYK1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Clone: 3G6S4
• Conjugate: Unconjugated
• Gene: TLR7
• Gene Alias: RGD1563357; RP23-139P21.3; Tlr7; TLR7-like; toll like receptor 7; toll-like receptor 7; toll-like receptor 7-like; UNQ248/PRO285
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51284
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid