Invitrogen™ TLR7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587550

Catalog No. PIPA587550

Description

Positive Samples: Cellular Location: Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endosome, Lysosome, Single-pass type I membrane protein, phagosome Immunogen sequence: FPKTLPCDVT LDVPKNHVIV DCTDKHLTEI PGGIPTNTTN LTLTINHIPD ISPASFHRLD HLVEIDFRCN CVPIPLGSKN NMCIKRLQIK PRSFSGLTYL KSLYLDGNQL LEIPQGLPPS LQLLSLEANN IFSIRKENLT ELANIEILYL GQNCYYRNPC YVSYSIEKDA FLNLTKLKVL SLKDNNVTAV PTVLPSTLTE L.

TLR7 is a 10 amino acid long highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 LRR (leucine-rich) repeats and a TIR domain. TLR7 plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is activated by infections with single-stranded RNA viruses, including influenza virus and vesicular stomatitis virus (VSV). TLR7 is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8. TLR7 also acts via MyD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. TLR7 recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.

Specifications

• Antigen: TLR7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TLR7
• Gene Alias: RGD1563357; RP23-139P21.3; Tlr7; TLR7-like; toll like receptor 7; toll-like receptor 7; toll-like receptor 7-like; UNQ248/PRO285
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 170743, 317468, 51284
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 0.51 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P58681, Q9NYK1
• Gene Symbols: TLR7
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 30-230 of human TLR7 (NP_0576461).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG