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Invitrogen™ TLR7 Polyclonal Antibody
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Catalog No. PIPA587550
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100 μL
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PIPA587550 100 μL
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Catalog No. PIPA587550 Supplier Invitrogen™ Supplier No. PA587550
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Description

Rabbit Polyclonal Antibody

Positive Samples: Cellular Location: Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endosome, Lysosome, Single-pass type I membrane protein, phagosome Immunogen sequence: FPKTLPCDVT LDVPKNHVIV DCTDKHLTEI PGGIPTNTTN LTLTINHIPD ISPASFHRLD HLVEIDFRCN CVPIPLGSKN NMCIKRLQIK PRSFSGLTYL KSLYLDGNQL LEIPQGLPPS LQLLSLEANN IFSIRKENLT ELANIEILYL GQNCYYRNPC YVSYSIEKDA FLNLTKLKVL SLKDNNVTAV PTVLPSTLTE L.

TLR7 is a 10 amino acid long highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 LRR (leucine-rich) repeats and a TIR domain. TLR7 plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is activated by infections with single-stranded RNA viruses, including influenza virus and vesicular stomatitis virus (VSV). TLR7 is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8. TLR7 also acts via MyD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. TLR7 recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TLR7
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.51 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene TLR7
Gene Accession No. P58681, Q9NYK1
Gene Alias RGD1563357; RP23-139P21.3; Tlr7; TLR7-like; toll like receptor 7; toll-like receptor 7; toll-like receptor 7-like; UNQ248/PRO285
Gene Symbols TLR7
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 30-230 of human TLR7 (NP_0576461).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 170743, 317468, 51284
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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