Invitrogen™ TLR9 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589960

Catalog No. PIPA589960

Description

Positive Samples: Mouse spleen, Rat spleen; Cellular Location: Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endosome, Lysosome, Single-pass type I membrane protein, phagosome Immunogen sequence: FPGLRYVDLS DNRISGASEL TATMGEADGG EKVWLQPGDL APAPVDTPSS EDFRPNCSTL NFTLDLSRNN LVTVQPEMFA QLSHLQCLRL SHNCISQAVN GSQFLPLTGL QVLDLSHNKL DLYHEHSFTE.

The protein encoded by this gene is a member of the Toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.

Specifications

• Antigen: TLR9
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Tlr9
• Gene Alias: CD289; Tlr9; toll like receptor 9; toll-like receptor 9; UNQ5798/PRO19605
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 338457, 54106, 81897
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.03 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q9EQU3, Q9NR96
• Gene Symbols: Tlr9
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 414-543 of human TLR9 (NP_0591381).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov