Invitrogen™ TLX Monoclonal Antibody (H6510)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ 434500

Catalog No. 43-450-0

Description

This antibody specifically recognizes human TLX and cross reacts with mouse and rat TLX.

Nuclear receptor TLX, a NR2 hepatocyte NF4-like receptor, has been shown to affect anterior brain differentiation, retinal development, and vision. It has been suggested that TLX targets genes for RAR beta2 and Pax2 during retinal development. Homozygous TLX mutant mice are viable at birth but exhibit reduced forebrain development and are more aggressive than wild-type mice. Mice with deleted TLX locus exhibit cerebral hypoplasia, blindness, and extreme aggression (fierce (frc) phenotype). TLX expression has been documented in mouse brain and eye. ESTs have been isolated from normal human brain libraries.

Specifications

• Antigen: TLX
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: Physiological saline with 0.1% sodium azide
• Gene Accession No.: Q64104, Q9Y466
• Gene Symbols: NR2E1
• Immunogen: Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human TLX (81-180 aa).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2a

• Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: H6510
• Conjugate: Unconjugated
• Gene: NR2E1
• Gene Alias: fc30e03; fc39f12; fierce; frc; HTll; Mtl1; Mtll; NR2D1; nr2e1; Nuclear receptor subfamily 2 group E member 1; nuclear receptor subfamily 2, group E, member 1; nuclear receptor TLX; Protein tailless homolog; tailes-related receptor; tailless; tailless homolog; TLL; Tlx; wu:fc30e03; wu:fc39f12; XTLL; zgc:100991
• Host Species: Mouse
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 21907, 684085, 7101
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 1 month. For long term storage store at -20°C
• Form: Liquid