Invitrogen™ TLX Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589187

Catalog No. PIPA589187

Description

Immunogen sequence: YFRGHKEENG AAAHFPSAAL PAPAFFTAVT QLEPHGLELA AVSTTPERQT LVSLAQPTPK YPHEVNGTPM YLYEVATESV CESAARLLFM SIKWAKSVPA FSTLSLQDQL MLLEDAWREL FVLGIAQWAI PVDANTLLAV SGMNGDNTDS QKLNKIISEI QALQEVVARF RQLRLDATEF ACLKCIVTFK AVPTHSGSEL RSFRNAAAIA ALQDEAQLTL NSYIHTRYPT QPCRFGKLLL LLPALRSISP STIEEVFFKK TIGNVPITRL LSDMYKSSDI; Positive Samples: HL-60, HepG2; Cellular Location: Nucleus.

Nuclear receptor TLX, a NR2 hepatocyte NF4-like receptor, has been shown to affect anterior brain differentiation, retinal development, and vision. It has been suggested that TLX targets genes for RAR beta2 and Pax2 during retinal development. Homozygous TLX mutant mice are viable at birth but exhibit reduced forebrain development and are more aggressive than wild-type mice. Mice with deleted TLX locus exhibit cerebral hypoplasia, blindness, and extreme aggression (fierce (frc) phenotype). TLX expression has been documented in mouse brain and eye. ESTs have been isolated from normal human brain libraries.

Specifications

• Antigen: TLX
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NR2E1
• Gene Alias: fc30e03; fc39f12; fierce; frc; HTll; Mtl1; Mtll; NR2D1; nr2e1; Nuclear receptor subfamily 2 group E member 1; nuclear receptor subfamily 2, group E, member 1; nuclear receptor TLX; Protein tailless homolog; tailes-related receptor; tailless; tailless homolog; TLL; Tlx; wu:fc30e03; wu:fc39f12; XTLL; zgc:100991
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7101
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.93 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9Y466
• Gene Symbols: NR2E1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 106-385 of human NR2E1/TLX (NP_0032601).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG