Invitrogen™ TLX1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA588816

Catalog No. PIPA588816

Description

Immunogen sequence: MEHLGPHHLH PGHAEPISFG IDQILNSPDQ GGCMGPASRL QDGEYGLGCL VGGAYTYGGG GSAAATGAGG AGAYGTGGPG GPGGPAGGGG ACSMGPLTGS YNVNMALAGG PGPGGGGGSS GGAGALSAAG VIRVPAHRPL AGAVAHPQPL ATGLPTVPSV PAMPGVNNLT GLTFPWMESN RRYTKDRFTG; Positive Samples: Jurkat, K562, Mouse spleen, Rat spleen; Cellular Location: Nucleus.

The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX1, also called homeobox11 (HOX11), as it is located outside of the four mammalian Hox clusters, is a DNA-binding nuclear transcription factor. TLX1 encodes a homeobox-domain containing protein and is containing a glycine and proline-rich amino terminus. TLX1 is required for maintenance of the developing spleen and cell survival. TLX1 is highly expressed in T-cell leukemia and lymphoid neoplasias as a result of translocation. TLX1-deficient mice have no spleen.

Specifications

• Antigen: TLX1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TLX1
• Gene Alias: homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch); homeobox protein Hox11; homeobox protein Hox-11; homeobox TLX-1; HOX11; Hox-11; LOW QUALITY PROTEIN: T-cell leukemia homeobox protein 1; MGC163402; proto-oncogene TCL-3; RGD1563655; SI:dZ46P4.1; T cell leukemia homeobox 1; T cell leukemia, homeobox 1; T-cell leukemia homeobox 1; T-cell leukemia homeobox protein 1; T-cell leukemia, homeobox 1; T-cell leukemia/lymphoma protein 3; TCL3; TLX1; Tlx-1; transcription factor; ztlx-1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21908, 3195, 499361
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.46 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P31314, P43345
• Gene Symbols: TLX1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human TLX1 (NP_0011824461).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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