Invitrogen™ TLX3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA585574

Catalog No. PIPA585574

Description

Keep as concentrated solution. Predicted reactivity: Mouse (100%), Xenopus laevis (100%), Chicken (100%), Bovine (100%). Positive Control: SK-N-SH, IMR32, SK-N-AS. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX3, also known as homeobox11-like1 (HOX11L2), is a DNA-binding nuclear transcription factor that is expressed in a subset of the primary sensory nervous system. TLX3, along with the related TLX1, is a selector transcription factor that promotes an excitatory glutamatergic neuronal phenotype over an inhibitory GABAergic phenotype opposing LBX1 signals during dorsal spinal cord development. Chromosomal translocations of the TLX3 gene have been shown to result in some forms of T-cell acute lymphoblastic leukemia (T-ALL).

Specifications

• Antigen: TLX3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TLX3
• Gene Alias: homeo box 11-like 2; homeobox 11-like 2; homeobox protein Hox-11L2; Homeobox TLX-3; HOX11L2; Respiratory neuron homeobox protein; RGD1564190; RNX; T cell leukemia, homeobox 3; T-cell leukemia homeobox 3; T-cell leukemia homeobox protein 3; T-cell leukemia, homeobox 3; Tlx1l2; TLX3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 27140, 30012
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O43711, O55144
• Gene Symbols: TLX3
• Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human TLX3.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG