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Tocris Bioscience™ TM 38837
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Catalog No. 71315
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Catalog No. Quantity
71-315 5 mg
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Catalog No. 71-315 Supplier Tocris Bioscience™ Supplier No. 7131/5
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Description

Highly potent CB1 inverse agonist; peripherally restricted

TM 38837 is a highly potent cannabinoid 1 receptor (CB1) inverse agonist (IC50 values are 8.5 nM and 605 nM for inhibition of [3H]-CP 55940 binding at CB1 and CB2 receptors, respectively). Displays 71-fold selectivity for CB1 receptors over CB2 receptors. Inhibits GTP binding to CB1-overexpressing cell membranes in vitro (EC50 = 18.5 nM). Peripherally restricted. Promotes fear behaviors when given by intracerebrovascular (icv) injection in mice.

Specifications

Chemical Name or Material 1-(2,4-Dichlorophenyl)-4-ethyl-N-1-piperidinyl-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]-2-thienyl]-1 H-pyrazole-3-carboxamide
CAS 1253641-65-4
Quantity 5 mg
Target Cannabinoid R1 / CB1 Inverse Agonists
Molecular Formula C30H25Cl2F3N4OS
Purity 0.98
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