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  5. Tocris Bioscience™ TM2 TEAD inhibitor

Tocris Bioscience™ TM2 TEAD inhibitor
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Catalog No. 791750
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Catalog No. Quantity
79-175-0 50 mg
79-171-0 10 mg
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Catalog No. 79-175-0 Supplier Tocris Bioscience™ Supplier No. 7917/50
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Description

Potent and reversible inhibitor of TEAD mediated Hippo/Yap signalling

TM2 TEAD inhibitor is a potent and reversible TEA domain transcription factor inhibitor (IC50 = 38 nM and 156 nM for TEAD4 auto-palmitoylation and TEAD2 palmitoylation, respectively). It inhibits TEAD-YAP association and transcriptional activity. TM2 TEAD inhibitor exhibits strong antiproliferation effects as a single agent or in combination with a MEK inhibitor in YAP-dependent cancer cells. Also inhibits YAP-dependent liver organoid growth ex vivo.

Specifications

Chemical Name or Material 4-[3-(2-Cyclohexylethoxy)benzoyl]-N-phenyl-1-piperazinecarboxamide
CAS 1008768-41-9
Quantity 50 mg
Target YAP1
Molecular Formula C26H33N3O3
Purity 0.98
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