Invitrogen™ TM2D1 Polyclonal Antibody

Catalog No.	Quantity
PIPA565960	100 μL

Catalog No. PIPA565960 Supplier Invitrogen™ Supplier No. PA565960

Description

Rabbit Polyclonal Antibody

Immunogen sequence: GSPNVIPRAHG QKNTRRDGTG LYPMRGPFKN LAL Highest antigen sequence identity to the following orthologs - mouse 38%, rat 35%.

Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the β-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer's disease. Proteolytic cleavage of APP leads to the formation of the Amyloid β/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer's patients. BBP (Beta-amyloid-binding protein), also known as TM2D1 (TM2 domain-containing protein 1), is a 207 amino acid multi-pass membrane protein containing a G protein-coupling module that allows for interaction with the β-amyloid peptide of APP. In cell culture, expression of BBP induces caspase-dependent vulnerability to β-amyloid peptide toxicity, suggesting that it is a target of β-amyloid and may be involved in the molecular pathophysiology of Alzheimer's disease.

Specifications

• Antigen: TM2D1
• Applications: Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: TM2D1
• Gene Accession No.: Q9BX74
• Gene Alias: 2310026L18Rik; AA990549; Amyloid-beta-binding protein; Bbp; beta-amyloid binding protein; beta-amyloid-binding protein; hBBP; mBBP; TM2 domain containing 1; TM2 domain-containing protein 1; Tm2d1
• Gene Symbols: TM2D1
• Host Species: Rabbit
• Immunogen: Recombinant Human TM2D1. Recombinant protein control fragment (Product #RP-106651).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 83941
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG