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Invitrogen™ TM2D1 Polyclonal Antibody
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Catalog No. PIPA5104180
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100 μL
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PIPA5104180 100 μL
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Catalog No. PIPA5104180 Supplier Invitrogen™ Supplier No. PA5104180
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total TM2D1.

Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the β-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer's disease. Proteolytic cleavage of APP leads to the formation of the Amyloid β/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer's patients. BBP (Beta-amyloid-binding protein), also known as TM2D1 (TM2 domain-containing protein 1), is a 207 amino acid multi-pass membrane protein containing a G protein-coupling module that allows for interaction with the β-amyloid peptide of APP. In cell culture, expression of BBP induces caspase-dependent vulnerability to β-amyloid peptide toxicity, suggesting that it is a target of β-amyloid and may be involved in the molecular pathophysiology of Alzheimer's disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TM2D1
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene TM2D1
Gene Accession No. Q99MB3, Q9BX74
Gene Alias 2310026L18Rik; AA990549; Amyloid-beta-binding protein; Bbp; beta-amyloid binding protein; beta-amyloid-binding protein; hBBP; mBBP; TM2 domain containing 1; TM2 domain-containing protein 1; Tm2d1
Gene Symbols TM2D1
Host Species Rabbit
Immunogen A synthesized peptide derived from human TM2D1(Accession Q9BX74), corresponding to amino acid residues S39-T89.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 362545, 83941, 94043
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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