TM4SF1/L6 Mouse anti-Human, PE, Clone: 877621, R&D Systems™

Mouse Monoclonal Antibody

Manufacturer:  R&D Systems FAB8164P

Catalog No. FAB8164P

Description

TM4SF1 (Transmembrane 4 L6 family Member 1; also L6 and M3s1) is a 23-28kDa member of the L6 tetraspanin family of molecules. It is expressed by fibroblasts, endothelial cells and a variety of tumor cells. TM4SF1 is embedded in both the plasma membrane and the membrane of late endocytic organelles. Here, it appears to be ubiquitinated, and to regulate endocytosis, an action that impacts effective cell migration. TM4SF1 is reported to interact with α5 and β1 integrins, and this may impact cell motility. It also suppresses the expression of CD63 and CD82, two molecules that impede cell mobility. Human TM4SF1 is a 202 amino acid (aa) 4-transmembrane (TM) glycoprotein. It contains a short N-terminal cytoplasmic region (aa 1-9), followed by four TM regions and another C-terminal cytoplasmic region (aa 183−202). Human TM4SF1 shares 78% and 80% aa sequence identity with mouse and rat TM4SF1, respectively.

Specifications

• Antigen: TM4SF1/L6
• Clone: 877621
• Dilution: Flow Cytometry 10 uL/10^6 cells
• Gene Accession No.: P30408
• Gene Alias: L6, M3s1, M3S1Tumor-associated antigen L6, Membrane component chromosome 3 surface marker 1, membrane component, chromosome 3, surface marker 1, TAAL6, TAAL6H-L6, transmembrane 4 L six family member 1, transmembrane 4 L6 family member 1, transmembrane 4 superfamily member 1
• Host Species: Mouse
• Isotype: IgG1
• Quantity: 100 Tests
• Storage Requirements: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 degreesC as supplied.
• Monoclonal or Polyclonal: Monoclonal
• Test Specificity: Detects human TM4SF1/L6 in ELISA. Stains human TM4SF1/L6 transfected cells but not irrelevant transfectants.

• Applications: Flow Cytometry
• Conjugate: R-PE
• Formulation: Supplied in a saline solution containing BSA and Sodium Azide. with Sodium Azide
• Format: Purified
• Gene Symbols: TM4SF1
• Immunogen: NS0 mouse myeloma cell line transfected with human TM4SF1/L6 Met1-Cys202 Accession # P30408
• Purification Method: Protein A or G purified from hybridoma culture supernatant
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4071
• Target Species: Human