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Invitrogen™ TM6SF2 Polyclonal Antibody
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Catalog No. PIPA569304
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100 μL
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Catalog No. Quantity
PIPA569304 100 μL
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Catalog No. PIPA569304 Supplier Invitrogen™ Supplier No. PA569304
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Description

Rabbit Polyclonal Antibody

This target displays homology in the following species: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 75%; Rat: 100%.

The TM6SF2 gene encodes transmembrane 6 superfamily member 2, a protein implicated in lipid metabolism and liver function. TM6SF2 is predominantly expressed in the liver and plays a crucial role in the regulation of lipid homeostasis, affecting the secretion of triglycerides and cholesterol. Genetic variations in TM6SF2, particularly the E167K polymorphism, have been associated with non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases. This variant influences lipid metabolism by altering the balance between lipid storage and secretion, contributing to hepatic steatosis and the progression of liver disease. Additionally, TM6SF2 mutations impact the risk of atherosclerosis due to their effects on lipid profiles, highlighting its significance in metabolic diseases. Research into TM6SF2 continues to uncover its roles in regulating lipid transport and metabolism, making it a potential target for therapeutic strategies addressing liver and cardiovascular health.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TM6SF2
Applications Western Blot, Surface Plasmon Resonance
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene TM6SF2
Gene Accession No. Q9BZW4
Gene Alias TM6SF2; Transmembrane 6 superfamily member 2
Gene Symbols TM6SF2
Host Species Rabbit
Immunogen synthetic peptide directed towards the C-terminal region of human TM6SF2.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 53345
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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