Invitrogen™ TMC1 Polyclonal Antibody

Catalog No.	Quantity
PIPA597128	100 μL

Catalog No. PIPA597128 Supplier Invitrogen™ Supplier No. PA597128

Description

Rabbit Polyclonal Antibody

Immunogen sequence: INILRLHTSM YFQCWAVMCC NVPEARVFKA SRSNNFYLGM LLLILFLSTM PVLYMIVSLP PSFDCGPFSG KNRMFEVIGE TLEHDFPSWM AKILRQLSNP G; Positive Samples: Mouse eye; Cellular Location: Membrane, Multi-pass membrane protein.

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.

Specifications

• Antigen: TMC1
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.44 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: TMC1
• Gene Accession No.: Q8R4P5, Q8TDI8
• Gene Alias: 4933416G09Rik; Beethoven; Beethoven protein; Bth; CWEA1; deafness protein; DFNA36; DFNB11; DFNB7; dn; Tmc1; transmembrane channel like 1; transmembrane channel-like 1; transmembrane channel-like gene family 1; transmembrane channel-like protein 1; Transmembrane cochlear-expressed protein 1; transmembrane, cochlear expressed 1; transmembrane, cochlear expressed, 1
• Gene Symbols: TMC1
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 600-700 of human TMC1 (NP_6196362).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 117531, 13409, 361739
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG